RapamycinFungusV1, Main, Exploration, bibRecord, 001627

Human cytomegalovirus protein UL38 inhibits host cell stress responses by antagonizing the tuberous sclerosis protein complex.

Identifieur interne : 001627 ( Main/Exploration ); précédent : 001626; suivant : 001628

Human cytomegalovirus protein UL38 inhibits host cell stress responses by antagonizing the tuberous sclerosis protein complex.

Auteurs : Nathaniel J. Moorman [États-Unis] ; Ileana M. Cristea ; Scott S. Terhune ; Michael P. Rout ; Brian T. Chait ; Thomas Shenk

Source :

Cell host & microbe [ 1934-6069 ] ; 2008.

RBID : pubmed:18407068

Descripteurs français

English descriptors

KwdEn :
- Capsid Proteins (physiology), Cells, Cultured (MeSH), Cytomegalovirus (physiology), Cytomegalovirus Infections (virology), Down-Regulation (MeSH), Fibroblasts (MeSH), Genes, Tumor Suppressor (MeSH), Heat-Shock Proteins (physiology), Humans (MeSH), Mechanistic Target of Rapamycin Complex 1 (MeSH), Multiprotein Complexes (MeSH), Proteins (MeSH), Signal Transduction (MeSH), TOR Serine-Threonine Kinases (MeSH), Transcription Factors (metabolism), Tuberous Sclerosis Complex 1 Protein (MeSH), Tuberous Sclerosis Complex 2 Protein (MeSH), Tumor Suppressor Proteins (metabolism), Virus Replication (MeSH).
MESH :
- chemical , metabolism : Transcription Factors, Tumor Suppressor Proteins.
- chemical , physiology : Capsid Proteins, Heat-Shock Proteins.
- physiology : Cytomegalovirus.
- virology : Cytomegalovirus Infections.
- Cells, Cultured, Down-Regulation, Fibroblasts, Genes, Tumor Suppressor, Humans, Mechanistic Target of Rapamycin Complex 1, Multiprotein Complexes, Proteins, Signal Transduction, TOR Serine-Threonine Kinases, Tuberous Sclerosis Complex 1 Protein, Tuberous Sclerosis Complex 2 Protein, Virus Replication.

Abstract

Human cytomegalovirus proteins alter host cells to favor virus replication. These viral proteins include pUL38, which prevents apoptosis. To characterize the mode of action of pUL38, we modified the viral genome to encode an epitope-tagged pUL38 and used rapid immunoaffinity purification to isolate pUL38-interacting host proteins, which were then identified by mass spectrometry. One of the cellular proteins identified was TSC2, a constituent of the tuberous sclerosis tumor suppressor protein complex (TSC1/2). TSC1/2 integrates stress signals and regulates the mammalian target of rapamycin complex 1 (mTORC1), a protein complex that responds to stress by limiting protein synthesis and cell growth. We showed that pUL38 interacts with TSC1 and TSC2 in cells infected with wild-type cytomegalovirus. Furthermore, TSC1/2 failed to regulate mTORC1 in cells expressing pUL38, and these cells exhibited the enlarged size characteristic of cytomegalovirus infection. Thus, pUL38 supports virus replication at least in part by blocking cellular responses to stress.

DOI: 10.1016/j.chom.2008.03.002
PubMed: 18407068
PubMed Central: PMC2759192

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<term>Heat-Shock Proteins (physiology)</term>
<term>Humans (MeSH)</term>
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<term>Signal Transduction (MeSH)</term>
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<term>Complexe-1 cible mécanistique de la rapamycine (MeSH)</term>
<term>Complexes multiprotéiques (MeSH)</term>
<term>Cytomegalovirus (physiologie)</term>
<term>Facteurs de transcription (métabolisme)</term>
<term>Fibroblastes (MeSH)</term>
<term>Gènes suppresseurs de tumeur (MeSH)</term>
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<term>Infections à cytomégalovirus (virologie)</term>
<term>Protéine-1 du complexe de la sclérose tubéreuse (MeSH)</term>
<term>Protéine-2 du complexe de la sclérose tubéreuse (MeSH)</term>
<term>Protéines (MeSH)</term>
<term>Protéines de capside (physiologie)</term>
<term>Protéines du choc thermique (physiologie)</term>
<term>Protéines suppresseurs de tumeurs (métabolisme)</term>
<term>Régulation négative (MeSH)</term>
<term>Réplication virale (MeSH)</term>
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<term>Humans</term>
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<front><div type="abstract" xml:lang="en">Human cytomegalovirus proteins alter host cells to favor virus replication. These viral proteins include pUL38, which prevents apoptosis. To characterize the mode of action of pUL38, we modified the viral genome to encode an epitope-tagged pUL38 and used rapid immunoaffinity purification to isolate pUL38-interacting host proteins, which were then identified by mass spectrometry. One of the cellular proteins identified was TSC2, a constituent of the tuberous sclerosis tumor suppressor protein complex (TSC1/2). TSC1/2 integrates stress signals and regulates the mammalian target of rapamycin complex 1 (mTORC1), a protein complex that responds to stress by limiting protein synthesis and cell growth. We showed that pUL38 interacts with TSC1 and TSC2 in cells infected with wild-type cytomegalovirus. Furthermore, TSC1/2 failed to regulate mTORC1 in cells expressing pUL38, and these cells exhibited the enlarged size characteristic of cytomegalovirus infection. Thus, pUL38 supports virus replication at least in part by blocking cellular responses to stress.</div>
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<Abstract><AbstractText>Human cytomegalovirus proteins alter host cells to favor virus replication. These viral proteins include pUL38, which prevents apoptosis. To characterize the mode of action of pUL38, we modified the viral genome to encode an epitope-tagged pUL38 and used rapid immunoaffinity purification to isolate pUL38-interacting host proteins, which were then identified by mass spectrometry. One of the cellular proteins identified was TSC2, a constituent of the tuberous sclerosis tumor suppressor protein complex (TSC1/2). TSC1/2 integrates stress signals and regulates the mammalian target of rapamycin complex 1 (mTORC1), a protein complex that responds to stress by limiting protein synthesis and cell growth. We showed that pUL38 interacts with TSC1 and TSC2 in cells infected with wild-type cytomegalovirus. Furthermore, TSC1/2 failed to regulate mTORC1 in cells expressing pUL38, and these cells exhibited the enlarged size characteristic of cytomegalovirus infection. Thus, pUL38 supports virus replication at least in part by blocking cellular responses to stress.</AbstractText>
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	Serveur d'exploration sur la rapamycine et les champignons
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Human cytomegalovirus protein UL38 inhibits host cell stress responses by antagonizing the tuberous sclerosis protein complex.

Human cytomegalovirus protein UL38 inhibits host cell stress responses by antagonizing the tuberous sclerosis protein complex.

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